Synonyms	C-C Motif Chemokine 3;G0/G1 Switch Regulatory Protein 19-1;Macrophage Inflammatory Protein 1-Alpha;MIP-1-Alpha;PAT 464.1;SIS-Beta;Small-Inducible Cytokine A3;Tonsillar Lymphocyte LD78 Alpha Protein;CCL3;G0S19-1;MIP1A;SCYA3
Species	Human
Expression_host	E.coli
Sequence	Ala 27-Ala 92
Accession	P10147
Mol_Mass	8.4 kDa
AP_Mol_Mass	8-11 kDa
Tag	None
Bio_Activity	Measure by its ability to chemoattract human PBMC using a concentration range of 5 -50 ng/mL.

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 0.1 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from sterile PBS,pH 8.5. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Human Chemokine (C-C Motif) Ligand 3 (CCL3) is a small cytokine belonging to the CC chemokine family. CCL3 is primarily expressed in T cells, B cells, and monocytes after antigen or mitogen stimulation. CCL3 exhibits chemoattractive and adhesive effects on lymphocytes. CCL3 exerts multiple effects on hematopoietic precursor cells and inhibits the proliferation of hematopoietic stem cells in vitro as well as in vivo. CCR1 and CCR5 have been identified as functional receptors for CCL3.

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