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Recombinant Human CSF2RA/GM-CSFR Protein (His Tag)

Uniprot : P15509
  • Cat.No.:PKSH033281

  • Expression host: HEK293 Cells

To Purchase PKSH033281

Size:
  • 10μg
  • 50μg
Price: $111
Qty:

Description

Synonyms Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha;GM-CSF-R-Alpha;GMCSFR-Alpha;GMR-Alpha;CDw116;CD116;CSF2RA;CSF2R;CSF2RY
Species Human
Expression_host HEK293 Cells
Sequence Glu23-Gly320
Accession P15509
Mol_Mass 35.5 kDa
AP_Mol_Mass 60 kDa
Tag C-His
Bio_Activity Measured by its ability to inhibit GM-CSF-dependent proliferation of TF‑1 human erythroleukemic cells. The ED50 for this effect is 0.5-2 μg/ml.

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.

Background

Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit α (CSF2RA) is a single-pass type I membrane protein which belongs to the type I cytokine receptor family of Type 5 subfamily. The CSF2RA gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes with some of the isoforms being membrane-bound and others being soluble. CSF2RA is a low affinity receptor for granulocyte-macrophage colony-stimulating factor. CSF2RA transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4).

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