Recombinant Human EGFR Protein (aa 668-1210, His &GST Tag)

    • Recombinant Human EGFR / HER1 / ErbB1 (aa 668-1210) Protein (His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human EGFR / HER1 / ErbB1 (aa 668-1210) Protein (His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human EGFR / HER1 / ErbB1 (aa 668-1210) Protein (His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030428

      Synonyms:ERBB;ERBB1;HER1;mENA;NISBD2;PIG61

      Size:
      • 20µg
      • 50µg
      Qty:
      - +
      Price: $486

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms ERBB;ERBB1;HER1;mENA;NISBD2;PIG61
      Species Human
      Expression_host Baculovirus-Insect cells
      Sequence Met 668-Ala 1210
      Accession NP_005219
      Mol_Mass 89.1 kDa
      Tag N-His-GST
      Bio_Activity The specific activity was determined to be 105 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.

      Properties

      Purity > 85 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.

      SDS-PAGE

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