Recombinant Human IL2RG/CD132 Protein (aa 1-254, Fc Tag)

The common gamma chain (γc) (or CD132); also known as interleukin-2 receptor subunit gamma or IL2RG; is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations; and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG); is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2; IL-4; IL-7; IL-9; IL-15 and interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (XSCID) is a rare and potentially fatal disease caused by mutations of IL2RG; the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross-linking data; the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor; together with the finding that IL-2R gamma associates with the IL-7 receptor; begins to elucidate why deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development; as seen in X-linked severe combined immunodeficiency.