Recombinant Human IL-23(IL23A&IL12B) Protein (His Tag)(Active)

    • Recombinant Human IL-23 / Interleukin-23(IL23A&IL12B) Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human IL-23 / Interleukin-23(IL23A&IL12B) Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human IL-23 / Interleukin-23(IL23A&IL12B) Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033619

      Synonyms:SGRF;IL-23p19;CLMF p40;IL-12 subunit p40;NKSF2;IL-23;IL-23A;IL23P19;P19

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $178

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      Overview

      Synonyms SGRF;IL-23p19;CLMF p40;IL-12 subunit p40;NKSF2;IL-23;IL-23A;IL23P19;P19
      Species Human
      Expression_host Human Cells
      Sequence Arg20-Pro189Ile23-Ser328
      Accession Q9NPF7&P29460
      Mol_Mass 55.2 kDa
      AP_Mol_Mass 60-90 kDa
      Tag C-His
      Bio_Activity Measured by its ability to induce STAT reporter activity in 293F human embryonic kidney cells. The ED50 for this effect is 307.2 ng/ml .

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.

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      MSDS for ELISA ISO 9001

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