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Recombinant Human LAG3/CD223 Protein (Fc Tag)(Active)

  • Cat.No.:PKSH033597

  • Expression host: Human Cells

To Purchase PKSH033597

Size:
  • 10μg
  • 50μg
Price: $111
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Description

Synonyms Lymphocyte activation gene 3 protein;LAG3;LAG-3;Protein FDC;CD223;LAG-3
Species Human
Expression_host Human Cells
Sequence Leu23-Leu450
Accession P18627
Application Functional ELISA
Mol_Mass 73.3 kDa
AP_Mol_Mass 70-90 kDa
Tag C-Fc
Bio_Activity Immobilized Human LAG-3-Fc at 5μg/ml(100 μl/well) can bind Human FGL1-mFc(Cat: PKSH033679). The ED50 of Human LAG-3-Fc is 2.1 ug/ml.

Properties

Purity > 95% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg as determined by the LAL method.
Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
Reconstitution Please refer to the printed manual for detailed information.

Background

Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.

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