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Recombinant Human Oncomodulin-1/OCM Protein (His Tag)

Uniprot : P0CE72

Cat.No.:PKSH032834
Expression host: E.coli

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Description

Synonyms	Oncomodulin-1;OM;Parvalbumin Beta;OCM;OCM1;OCMN
Species	Human
Expression_host	E.coli
Sequence	Met 1-Ser109
Accession	P0CE72
Mol_Mass	14.3 kDa
AP_Mol_Mass	16 kDa
Tag	N-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 50mM Tris-HCl, 100mM NaCl, pH 8.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the print
Reconstitution	Please refer to the printed manual for detailed information.

Background

Oncomodulin-1 (OM) is a small, calcium-binding protein and a macrophage-derived growth factor, which can promote axon regeneration in retinal ganglion cells. Oncomodulin-1 is constitutively secreted by activated macrophages in the vitreous and retina in response to inflammatory conditions that promote optic nerve regeneration. Oncomodulin-1 binds RGCs with high affinity in vitro, but only when cAMP is pharmacologically elevated or if the membrane is permeabilized allowing Oncomodulin-1 access to the cytosolic compartment. Oncomodulin-1 is a member of the superfamily of calmodulin proteins and is a high-affinity calcium ion-binding protein and contains 2 EF-hand domains. OM is found in early embryonic cells in the placenta and also in tumors. It has some calmodulin-like activity with respect to enzyme activation and growth regulation.

Citations

Reviews/Q&A

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Q&A

F****dSubmitted [ Oct 14 2021 ]

Asked: We have contacted many places, but in vain. Can you suggest someone or somewhere specializing in neuron regeneration or sth that can be of help? Thanks in advance

<******************eSubmitted [ Oct 14 2021 ]

Answered: I am sorry that I am not clear about the area in neuron regeneration.

F****dSubmitted [ Oct 13 2021 ]

Asked: Can this product help people who have lost a big chunk of their eyesight because of methanol toxicity, sth like glaucoma?? I need it for my brother

******************eSubmitted [ Oct 13 2021 ]

Answered: I'm sorry that our products are dedicated to scientific research only. It is suggest that you take your brother to a professional hospital for treatment.

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