Recombinant Human PTP1B / PTPN1 Protein (His Tag)

    • Recombinant Human PTP1B / PTPN1 Protein (His Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    <
    >
    • Recombinant Human PTP1B / PTPN1 Protein (His Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human PTP1B / PTPN1 Protein (His Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030416

      Synonyms:PTP1B;PTPN1

      Size:
      • 50µg
      • 100µg
      Qty:
      - +
      Price: $584

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms PTP1B;PTPN1
      Species Human
      Expression_host E.coli
      Sequence Glu 2-Asn 321
      Accession NP_002818.1
      Mol_Mass 38 kDa
      AP_Mol_Mass 38 kDa
      Tag N-His
      Bio_Activity Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor (aa988-998) phosphopeptide substrate, R&D Systems, Catalog # ES006.The specific activity is > 15 nmoles/min/μg.

      Properties

      Purity > 95 % as determined by reducing SDS-PAGE.
      Endotoxin Please contact us for more information.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as sterile 10 mM Hepes, 150 mM NaCl, 1 mM DTT, pH 7.5
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein phosphatase domain and is expressed in many tissues. PTP1B is localized to the cytoplasmic face of the endoplasmic reticulum. PTP1B was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of PTP1B in cell growth control, and cell response to IFN stimulation.

      SDS-PAGE

      • Show all (0)
      • Reviews (0)
      • Q&A (0)
      ... Show All Show Less
      MSDS for ELISA

      Browsing History


        People Also Bought