Recombinant Human Thioredoxin / TXN / SASP Protein

    • Recombinant Human Thioredoxin / TXN / SASP Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human Thioredoxin / TXN / SASP Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human Thioredoxin / TXN / SASP Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030450

      Synonyms:DKFZp686B1993;MGC61975;RP11-427L11.1;TRDX;TRX;TRX1;TXN

      Size:
      • 200 µg
      • 500 µg
      Qty:
      - +
      Price: $285

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms DKFZp686B1993;MGC61975;RP11-427L11.1;TRDX;TRX;TRX1;TXN
      Species Human
      Expression_host E.coli
      Sequence Met 1-Val 105
      Accession P10599
      Mol_Mass 11.7 kDa
      AP_Mol_Mass 14 kDa
      Bio_Activity Measured by its ability to catalyze the reduction of insulin. The specific activity is 5-9 pmoles/min/μg.2. Measured by its ability to catalyze the reduction of insulin. The reaction leads toprecipitation, which can be measured by absorbance at 650 nm. The specific activity is 5-10 A650/min/mg.

      Properties

      Purity > 97 % as determined by reducing SDS-PAGE.
      Endotoxin Please contact us for more information.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.5
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Thioredoxin, also known as ATL-derived factor, Surface-associated sulphydryl protein, SASP and TXN, is a nucleus, cytoplasm and secreted protein which belongs to the thioredoxin family. Thioredoxins are proteins that act as antioxidants by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange. Thioredoxins are found in nearly all known organisms and are essential for life in mammals. Thioredoxin / TXN participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Thioredoxin / TXN plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Thioredoxin / TXN nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Thioredoxin / TXN induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.

      SDS-PAGE

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      MSDS for ELISA

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