Recombinant Human TIGIT Protein (His & Avi Tag)

    • Recombinant Human TIGIT / VSIG9 / VSTM3 Protein (C-His-Avi)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human TIGIT / VSIG9 / VSTM3 Protein (C-His-Avi)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human TIGIT / VSIG9 / VSTM3 Protein (C-His-Avi)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033793

      Synonyms:T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9

      Size:
      • 20μg
      • 100μg
      Qty:
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      Price: $342

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      Overview

      Synonyms T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9
      Species Human
      Expression_host Human Cells
      Sequence Met22-Pro141
      Accession Q495A1
      Mol_Mass 15.9 kDa
      AP_Mol_Mass 17-23 kDa
      Tag C-His-Avi

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the CD28 family within the Ig superfamily of proteins. TIGIT is expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155 and Nectin-2 that appear on dendritic cells (DC) and endothelium. Ligation of TIGIT on T cells down-regulates TCR-mediated activation and subsequent proliferation, while NK cell TIGIT ligation blocks NK cell cytotoxicity. Through CD155 and Nectin-2, which also interact with DNAM-1/CD226 and CD96/Tactile, TIGIT is part of an interacting network of Ig superfamily members that may augment or oppose each other. In particular, TIGIT binding to CD155 can antagonize the effects of DNAM1.

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      MSDS for ELISA ISO 9001

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