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Recombinant Macaca nemestrina PCSK9/Proprotein Convertase 9 Protein (His Tag)

Uniprot : A8T662

Cat.No.:PKSQ050064
Expression host: HEK293 Cells

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Description

Synonyms	Proprotein Convertase Subtilisin/Kexin Type 9;Proprotein Convertase 9;PC9;Subtilisin/Kexin-Like Protease PC9;PCSK9
Species	Macaca nemestrina
Expression_host	HEK293 Cells
Sequence	Gln31-Gln152&Ser153-Gln692
Accession	A8T662
Mol_Mass	14&59 kDa
AP_Mol_Mass	16-21&55-77 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 0.1M Arg, 0.1M Glu, 20% glycerol, 0.01% tween20, 5% Trehalose, pH 6.0.
Reconstitution	Not Applicable

Background

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development.

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