Recombinant Mouse PD-L1/B7-H1/CD274 Protein (His Tag) (Active)

    • Recombinant Mouse  PD-L1 Protein (His Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Mouse  PD-L1 Protein (His Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Mouse  PD-L1 Protein (His Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040919

      Synonyms:A530045L16Rik Protein, Mouse;B7h1 Protein, Mouse;Pdcd1l1 Protein, Mouse;Pdcd1lg1 Protein, Mouse;Pdl1 Protein, Mouse

      Size:
      • 100 μg
      • 200 μg
      Qty:
      - +
      Price: $454

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms A530045L16Rik Protein, Mouse;B7h1 Protein, Mouse;Pdcd1l1 Protein, Mouse;Pdcd1lg1 Protein, Mouse;Pdl1 Protein, Mouse
      Species Mouse
      Expression_host HEK293 Cells
      Sequence Met 1-Thr 238
      Accession NP_068693.1
      Application Functional ELISA
      Mol_Mass 26.3 kDa
      AP_Mol_Mass 40-45 kDa
      Tag C-His
      Bio_Activity Measured by its binding ability in a functional ELISA. Immobilized recombinant mouse PD1-L1 at 1 µg/ml (100 μl/well) can bind mouse PD1 with a linear range of 6.25-400 ng/ml.

      Properties

      Purity > 98 % as determined by SDS-PAGE
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

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      MSDS for ELISA ISO 9001

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