Recombinant Mouse Sonic Hedgehog/SHH (C25II) Protein (Active)

    • Recombinant Mouse Sonic Hedgehog / Shh (C25II) Protein-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Mouse Sonic Hedgehog / Shh (C25II) Protein-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Mouse Sonic Hedgehog / Shh (C25II) Protein-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSM041278

      Synonyms:Sonic Hedgehog Protein; SHH; HHG-1; SHH

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $129

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms Sonic Hedgehog Protein; SHH; HHG-1; SHH
      Species Mouse
      Expression_host E.coli
      Sequence Cys25-Gly198(Cys25Ile-Ile)
      Accession Q62226
      Application Functional ELISA
      Mol_Mass 19.8 kDa
      AP_Mol_Mass 18-20 kDa
      Bio_Activity Immobilized Human SHH at 1μg/ml(100 μl/well) can bind Human BOC-His(Cat: PKSH032123).

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 1mM DTT, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Mouse Sonic Hedgehog Homolog (SHH) belongs to a three-protein family called Hedgehog. The other two family members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH). Hedgehog proteins are key signaling molecules in embryonic development. SHH is expressed in various embryonic tissues and plays critical roles in regulating the patterning of many systems, such as limbs and brain. SHH also plays an important role in adult, including the division of adult stem cells and the development of certain cancers and other diseases.Mouse Shh is synthesized as a 437 aa precursor that contains a 24 aa signal sequence and a 413 aa mature region. The mature region is autocatalytically processed into a nonglycosylated, 20 kDa, 174 aa N-terminal fragment (Shh-N), and a catalytic-processing,glycosylated, 34 kDa, 239 aa C-terminal fragment. The 20 kDa Shh-N fragment is the core of the active hedgehog molecule. Mouse Shh-N is 99%, 98%, and 100% aa identical to human, rat and gerbil Shh-N, respectively.

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      MSDS for ELISA ISO 9001

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