Alternate Names	Integrin alpha-M,Itgam,CD11 antigen-like family member B,CR-3 alpha chain,Leukocyte adhesion receptor MO1,CD11b
Swissprot	P05555,P11215
References	1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Springer TA. 1994. Cell 76:301. 3. Coxon A, et al. 1996. Immunity 5:653.

Product Details

Form	Liquid
Clone No.	M1/70(See Other Available Formats)
Host	Rat
Isotype	Rat IgG2b, κ
Isotype Control	PE Rat IgG2b, κ Isotype Control[LTF-2] [Product E-AB-F09842D]
Reactivity	Human,Mouse
Application	FCM (See the Application Description)
Storage Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Recommended Use	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Shipping	Biological ice pack at 4℃
Stability & Storage	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Conjugation	PE
	PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter).

How to select the appropriate detection channel through the spectrogram?

Background

CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

Protocols & Troubleshootings

Related Protocols	Staining Cell Surface Targets for Flow Cytometry
Troubleshooting	Troubleshooting for Flow Cytometry

Alternative Formats

Product Name	Sizes	Price
AF/LE Purified Anti-Mouse/Human CD11b Antibody[M1/70]	50μg, 500μg, 1mg	Check More
Purified Anti-Mouse/Human CD11b Antibody[M1/70]	25μg, 100μg	Check More
Biotin Anti-Mouse/Human CD11b Antibody[M1/70]	25μg, 100μg	Check More
FITC Anti-Mouse/Human CD11b Antibody[M1/70]	50Tests, 100Tests, 100Tests×2	Check More
APC Anti-Mouse/Human CD11b Antibody[M1/70]	50Tests, 100Tests, 100Tests×2	Check More
PerCP Anti-Mouse/Human CD11b Antibody[M1/70]	50Tests, 100Tests, 100Tests×2	Check More
PE/Cyanine5 Anti-Mouse/Human CD11b Antibody[M1/70]	50Tests, 100Tests, 100Tests×2	Check More
PE/Cyanine7 Anti-Mouse/Human CD11b Antibody[M1/70]	50Tests, 100Tests, 100Tests×2	Check More
PE/Cyanine5.5 Anti-Mouse/Human CD11b Antibody[M1/70]	50Tests, 100Tests, 100Tests×2	Check More
PerCP/Cyanine5.5 Anti-Mouse/Human CD11b Antibody[M1/70]	50Tests, 100Tests, 100Tests×2	Check More
Elab Fluor^® 488 Anti-Mouse/Human CD11b Antibody[M1/70]	50Tests, 100Tests, 100Tests×2	Check More
Elab Fluor^® 647 Anti-Mouse/Human CD11b Antibody[M1/70]	50Tests, 100Tests, 100Tests×2	Check More
PE/Elab Fluor^® 594 Anti-Mouse/Human CD11b Antibody[M1/70]	50Tests, 100Tests, 100Tests×2	Check More
Elab Fluor^® Violet 450 Anti-Mouse/Human CD11b Antibody[M1/70]	50Tests, 100Tests, 100Tests×2	Check More
Elab Fluor^® Red 780 Anti-Mouse/Human CD11b Antibody[M1/70]	50Tests, 100Tests, 100Tests×2	Check More
FITC Anti-Mouse/Human CD11b Antibody[M1/70]	25μg, 100μg	Check More
PE Anti-Mouse/Human CD11b Antibody[M1/70]	25μg, 100μg	Check More
APC Anti-Mouse/Human CD11b Antibody[M1/70]	25μg, 100μg	Check More
PerCP Anti-Mouse/Human CD11b Antibody[M1/70]	25μg, 100μg	Check More
PE/Cyanine5 Anti-Mouse/Human CD11b Antibody[M1/70]	25μg, 100μg	Check More
PE/Cyanine7 Anti-Mouse/Human CD11b Antibody[M1/70]	25μg, 100μg	Check More
PE/Cyanine5.5 Anti-Mouse/Human CD11b Antibody[M1/70]	25μg, 100μg	Check More
PerCP/Cyanine5.5 Anti-Mouse/Human CD11b Antibody[M1/70]	25μg, 100μg	Check More
Elab Fluor^® 488 Anti-Mouse/Human CD11b Antibody[M1/70]	25μg, 100μg	Check More
Elab Fluor^® 647 Anti-Mouse/Human CD11b Antibody[M1/70]	25μg, 100μg	Check More
PE/Elab Fluor^® 594 Anti-Mouse/Human CD11b Antibody[M1/70]	25μg, 100μg	Check More
Elab Fluor^® Violet 450 Anti-Mouse/Human CD11b Antibody[M1/70]	25μg, 100μg	Check More
Elab Fluor^® Red 780 Anti-Mouse/Human CD11b Antibody[M1/70]	25μg, 100μg	Check More

Citations

Marine Drugs (2022) IF: 5.118
In Vitro and In Vivo Dendritic Cell Immune Stimulation Effect of Low Molecular Weight Fucoidan from New Zealand Undaria pinnatifida

DOI: 10.3390/md20030197

PMID: 35323496
Sample: Dendritic cells (DCs)
Food & Function (2021) IF: 5.396
The petroleum ether extract of Brassica rapa L. induces apoptosis of lung adenocarcinoma cells via the mitochondria-dependent pathway

DOI: 10.1039/D1FO01547H

PMID: 34523644
Sample: spleen
Human Vaccines & Immunotherapeutics (2018) IF: 2.229
Pleurotus ferulae polysaccharides improve the antitumor efficacy of therapeutic human papillomavirus dendritic cell-based vaccine

DOI: 10.1080/21645515.2018.1547604

PMID: 30427754
Sample: Cell culture supernatant
Journal of Thoracic Disease (2021) IF: 2.895
Mesenchymal stem cells transfected with anti-miRNA-204-3p inhibit acute rejection after heart transplantation by targeting C-X-C motif chemokine receptor 4 (CXCR4) in vitro

DOI: 10.21037/jtd-21-1293

PMID: 34527345
Sample: MSCs

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