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Recombinant Cynomolgus Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-6His)

Uniprot : A0A2K5UY47

Cat.No.:PKSQ050096
Expression host: HEK293 Cells

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Description

Synonyms	Angiopoietin-related protein 4;425O18-1;Angiopoietin-like protein 4;Fasting-induced adipose factor;Hepatic fibrinogen/angiopoietin-related protein;HFARP;Secreted protein Bk89;Angptl4;Farp;Fiaf;Ng27
Species	Cynomolgus macaques
Expression_host	HEK293 Cells
Sequence	Phe20-Thr263
Accession	A0A2K5UY47
Mol_Mass	27.1 kDa
AP_Mol_Mass	30-40 kDa
Tag	C-His
Bio_Activity	Loaded Anti-Human Siglec15 mAb-mFc on AMQ Biosensor, can bind Cynomolgus Siglec-15-His with an affinity constant of 0.30 nM as determined in BLI assay.

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, 150mMNaCl, 0.3% Chaps, 5% Trehalose, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer informati
Reconstitution	Please refer to the printed manual for detailed information.

Background

Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO?-terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type Ig domains which have no binding activity. Siglecs differ in the number of these C2-type domains. Human Siglec-15 consists of a 244 amino acid (aa) extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts.

Citations

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