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Recombinant Human Arylsulfatase A/ARSA Protein (His Tag)

Uniprot : P15289

Cat.No.:PKSH032093
Expression host: HEK293 Cells

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Description

Synonyms	Arylsulfatase A;ASA;Cerebroside-Sulfatase;ARSA
Species	Human
Expression_host	HEK293 Cells
Sequence	Arg19-Ala507
Accession	AAH14210.2
Mol_Mass	52.9 kDa
AP_Mol_Mass	50-65 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 300mM NaCl, pH 8.0.
Reconstitution	Not Applicable

Background

Arylsulfatase A (ARSA) is a lysosomal enzyme that breaks down Cerebroside 3-Sulfate, a major constituent of the myelin sheet, into Cerebroside and Sulfate. The ARSA deficiency results in Metachromatic Leukodystrophy (MLD), a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms. Recombinant Human ARSA corresponds to the ARSA mature peptide and has sulfatase activity.

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