Recombinant Human B7-DC/PD-L2/CD273 Protein (His Tag)

Programmed death ligand 2 (PD-L2); also referred to as B7-DC and CD273; is a member of the B7 family of proteins including B7-1; B7-2; B7-H2; B7-H1 (PD-L1); and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain; a transmembrane region; and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells; placental endothelium and medullary thymic epithelial cells; and can be induced by LPS in B cells; INF-γ in monocytes; or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1; member of the CD28/CTLA4 family expressed on activated lymphoid cells; and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.