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Recombinant Human Cadherin-11/CDH11 Protein (His Tag)

Citations(1)Uniprot : Q96CZ9

Cat.No.:PKSH032136
Expression host: HEK293 Cells

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Description

Synonyms	Cadherin 11 Type 2 OB-cadherin (Osteoblast);Cadherin 11 Type 2 OB-Cadherin (Osteoblast) Isoform CRA_c;CDH11
Species	Human
Expression_host	HEK293 Cells
Sequence	Phe23-Thr617
Accession	Q96CZ9
Mol_Mass	66.6 kDa
AP_Mol_Mass	82 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed man
Reconstitution	Please refer to the printed manual for detailed information.

Background

Cadherin-11 is a type II classical cadherin member of the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherins interact with themselves in a homophilic manner in connecting cells; and thus contribute to the sorting of heterogeneous cell types. Cadherin-11 contains five cadherin domains and is mainly expressed in the brain. Mature cadherin proteins consists of a large N-terminal extracellular domain; a single membrane-spanning domain; and a small highly conserved C-terminal cytoplasmic domain. It is shown that Cadherin-11 is a viable molecular target for therapeutic intervention in Glioblastoma multiforme.

Citations

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022) IF: 12.779

Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody

DOI: 10.1073/pnas.2209563119
PMID: 36256815

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