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Recombinant Human Carbonic Anhydrase 8/CA8 Protein (His Tag)

Uniprot : P35219

Cat.No.:PKSH032165
Expression host: E.coli

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Description

Synonyms	Carbonic Anhydrase-Related Protein;CARP;Carbonic Anhydrase VIII;CA-VIII;CA8;CALS;CAMRQ3;MGC120502;MGC99509
Species	Human
Expression_host	E.coli
Sequence	Ala2-Gln290
Accession	P35219
Mol_Mass	34.0 kDa
AP_Mol_Mass	40 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 1mM DTT, pH 8.5.
Reconstitution	Not Applicable

Background

Carbonic Anhydrase 8 (CA8) belongs to the alpha-carbonic anhydrase family. Alpha-carbonic anhydrase is a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Because CA8 has some sequence similarity with other known carbonic anhydrase genes, it was firstly called as CA-related protein. Nevertheless, CA8 does not have a carbonic anhydrase catalytic activity. Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3), which is a congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mild mental retardation.

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