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Recombinant Human CD93/C1QR1 Protein (aa 1-580, His Tag)

Uniprot : Q9NPY3

Cat.No.:PKSH030806
Expression host: HEK293 Cells

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50μg

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Description

Synonyms	Complement Component C1q Receptor;C1q/MBL/SPA Receptor;C1qR;C1qR(p);C1qRp;CDw93;Complement Component 1 q Subcomponent Receptor 1;Matrix-Remodeling-Associated Protein 4CD93;C1QR1;MXRA4
Species	Human
Expression_host	HEK293 Cells
Sequence	Met 1-Lys 580
Accession	Q9NPY3
Mol_Mass	59.6 kDa
AP_Mol_Mass	100 kDa
Tag	C-His

Properties

Purity	> 90 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from sterile PBS, pH 7.4 Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protein expressed on monocytes; neutrophils; endothelial cells; and stem cells. CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. CD93/C1qR; a receptor expressed during early B-cell development; is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive; memory; and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells; including long-lived plasma cells that showed decreased cell cycle activity; high levels of isotype-switched Ig secretion; and modification of the transcriptional network. CD93 is important for the maintenance of plasma cells in bone marrow niches.

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