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Recombinant Human EDNRB/Endothelin B Receptor Protein (Fc Tag)

Uniprot : P24530

Cat.No.:PKSH030546
Expression host: HEK293 Cells

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100μg

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Description

Synonyms	ABCDS;ET-B;ET-BR;ETB;ETBR;ETRB;HSCR;HSCR2;WS4A
Species	Human
Expression_host	HEK293 Cells
Sequence	Met 1-Lys101
Accession	NP_000106.1
Mol_Mass	34.4 kDa
AP_Mol_Mass	47.5&43.7 kDa
Tag	C-mFc

Properties

Purity	> 85 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from sterile PBS, pH 7.4 Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

The hypermethylation of EDNRB gene was remarkably related to infiltration and metastasis of gastric cancer and may attribute to the tumor progression. EDNRB is a new candidate tumor suppressor gene which is often down-regulated or even silenced by promoter hypermethylation in various human cancers. Low EDNRB expression played a role in the progression of ACC tumors. The autosomal recessive mutation in EDNRB may underlie a part of WS1 with the current diagnostic criteria, and supported that Hirschsprung's disease is a multifactorial genetic disease which requires additional factors.

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