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Recombinant Human FBPase 1/FBP1 Protein (Human Cells, His Tag)

Uniprot : P09467

Cat.No.:PKSH033277
Expression host: HEK293 Cells

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Description

Synonyms	Fructose-1;6-bisphosphatase 1;D-fructose-1;6-bisphosphate 1-phosphohydrolase 1;FBP;FBPase 1
Species	Human
Expression_host	HEK293 Cells
Sequence	Ala2-Gln338
Accession	P09467
Mol_Mass	37.8 kDa
AP_Mol_Mass	35-38 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, 1mM DTT, 1mMEDTA, 10% Glycerol, pH 8.0.
Reconstitution	Not Applicable

Background

Fructose-1;6-bisphosphatase 1(FBP1) is a homotetramer protein and belongs to the FBPase class 1 family. It involves in carbohydrate biosynthesis; gluconeogenesis pathway. FBP1 is a gluconeogenesis regulatory protein which catalyzes the hydrolysis of fructose 1;6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBP1 deficiency is associated with hypoglycemia and metabolic acidosis. FBP1 regulates mouse endogenous glucose production. FBP1 coupled with phosphofructokinase (PFK) takes part in the metabolism of pancreatic islet cells.

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