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Recombinant Human FcRn & B2M Heterodimer Protein (His Tag)

Uniprot : P55899&P61769

Cat.No.:PKSH032422
Expression host: HEK293 Cells

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Description

Synonyms	IgG receptor FcRn;Neonatal Fc receptor;FCRN
Species	Human
Expression_host	HEK293 Cells
Sequence	Ala24-Leu290&Ile21-Met 119
Accession	AAF72596&P61769
Mol_Mass	31.2&11.7 kDa
AP_Mol_Mass	13&37 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, pH7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed m
Reconstitution	Please refer to the printed manual for detailed information.

Background

FcRn complex consist of two subunits: IgG receptor FcRn large subunit p51（alpha chain) and Beta-2-microglobulin（Beta chain). The complexes is similar in structure to MHC class I-like heterodimer. Beta-2-microglobulin involved in the presentation of peptide antigens to the immune system. FcRn binds to the Fc region of monomeric immunoglobulins gamma, mediates the uptake of IgG from milk,Possible role in transfer of immunoglobulin G from mother to fetus. A principal component of antibody transport is the neonatal receptor for the Fc portion of immunoglobulin, a heterodimer of a MHC-1 alpha-chain homolog ( FcRn ) and beta-2-microglobulin ( B2M ).

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