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Recombinant Human GMPR Protein (Human Cells, His Tag)

Uniprot : P36959

Cat.No.:PKSH033290
Expression host: HEK293 Cells

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Description

Synonyms	GMP Reductase 1;Guanosine 5'-Monophosphate Oxidoreductase 1;Guanosine Monophosphate Reductase 1;GMPR;GMPR1
Species	Human
Expression_host	HEK293 Cells
Sequence	Met 1-Ser345
Accession	AAH08281.1
Mol_Mass	38.5 kDa
AP_Mol_Mass	40 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 40% Glycerol, 150mM NaCl, 1mM DTT, pH 8.0.
Reconstitution	Not Applicable

Background

GMP Reductase 1 (GMPR) is a member of the IMPDH/GMPR family. GMPR exists as a homotetramer and catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase; nucleoside and nucleotide derivatives of G to A nucleotides; and in maintaining the intracellular balance of A and G nucleotides. GMP reductase gene expression may be regulated by MITF. At least two different alleles are known.

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