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Recombinant Human Interleukin-17F/IL-17F Protein (His Tag)

Uniprot : Q96PD4

Cat.No.:PKSH032624
Expression host: HEK293 Cells

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Description

Synonyms	Interleukin-17F;IL-17F;Cytokine ML-1;Interleukin-24;IL-24;IL17F;IL24
Species	Human
Expression_host	HEK293 Cells
Sequence	Arg31-Gln163
Accession	AAH70124.1
Mol_Mass	16.0 kDa
AP_Mol_Mass	19 kDa
Tag	C-His
Bio_Activity	Immobilized Mouse IL-17RA-Fc at 1μg/ml (100 μl/well)can bind Human IL-17F-His.The ED₅₀ of Human IL-17F-His is 47.94 ng/ml.

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Interleukin-17F (IL-17F) exists in a disulfide-linked heterodimer that belongs to the IL-17 family. IL-17F is expressed in activated; but not resting; CD4+ T-cells and activated monocytes. IL-17F has been shown to stimulate the production of several other cytokines; including IL-6; IL-8; and granulocyte colony-stimulating factor. IL-17F can regulate cartilage matrix turnover and stimulates PBMC and T-cell proliferation. IL-17F is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2; TGFB1/TGFB; and monocyte chemoattractant protein-1. Defects in IL-17F are the cause of familial candidiasis type 6 (CANDF6).

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