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Recombinant Human LMAN2/VIP36 Protein (E.coli, His Tag)

Uniprot : Q12907

Cat.No.:PKSH030834
Expression host: E.coli

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100μg

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Description

Synonyms	Vesicular Integral-Membrane Protein VIP36;Glycoprotein GP36b;Lectin Mannose-Binding 2;Vesicular Integral-Membrane Protein 36;VIP36;LMAN2;C5orf8
Species	Human
Expression_host	E.coli
Sequence	As p45-Arg 322
Accession	Q12907
Mol_Mass	33.2 kDa
AP_Mol_Mass	30 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	Please contact us for more information.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from sterile 50mM Tris, pH 8.5 Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

The L-type lectin LMAN2 (also known as VIP36) appears to be specifically required for the accumulation of GPRC5B in the Golgi complex and restriction of GPRC5B transport along the exosomal pathway. This may occur due to interference with the adaptor protein GGA1-mediated trans Golgi network-to-endosome transport of GPRC5B.A Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B in which CD2AP facilitates the entry and LMAN2 impedes the exit of the flux; respectively.

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