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Recombinant Human Neurocalcin-δ/NCALD Protein (His Tag)

Uniprot : P61601
  • Cat.No.:PKSH032796

  • Expression host: E.coli

To Purchase PKSH032796

Size:
  • 10μg
  • 50μg
Price: $223
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Description

Synonyms Neurocalcin-Delta;NCALD
Species Human
Expression_host E.coli
Sequence Met 1-Phe193
Accession P61601
Mol_Mass 24.4 kDa
AP_Mol_Mass 20 kDa
Tag N-His
Bio_Activity Not validated for activity

Properties

Purity > 90 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 1mM DTT, 40% Glycerol, pH 8.0.
Reconstitution Not Applicable

Background

Neurocalcin-delta (NCALD) is a neuronal calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family. It expressed in mammalian brains. NCALD contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein possesses a Ca2+ /myristoyl switch. It is cytosolic at resting calcium levels. However, elevated intracellular calcium levels induce a conformational change which exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. NCALD protein is thought to be a regulator of G protein-coupled receptor signal transduction.

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