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Recombinant Human Nogo Receptor/NgR Protein (His Tag)

Uniprot : Q9BZR6

Cat.No.:PKSH033418
Expression host: HEK293 Cells

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Description

Synonyms	Reticulon-4 Receptor;Nogo Receptor;NgR;Nogo-66 Receptor;RTN4R;NOGOR
Species	Human
Expression_host	HEK293 Cells
Sequence	Cys27-Ser447
Accession	Q9BZR6
Mol_Mass	46.3 kDa
AP_Mol_Mass	60-90 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Nogo Receptor (NgR) is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family. Human NgR is predominantly expressed in neurons and their axons in the central nervous systems. As a receptor for myelin-derived proteins Nogo; myelin-associated glycoprotein (MAG) and myelin oligodendrocyte glycoprotein (OMG); NgR mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. NgR may be proposed as a potential drug target for treatment of various neurological conditions. Additionally; NgR may play a role in regulating the function of gap junctions.

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