Synonyms	6-phosphofructokinase;muscle type;Phosphofructo-1-kinase isozyme A;Phosphofructokinase 1;Phosphohexokinase;PFKM;PFKX;ATP-PFK;GSD7;PFK-1;PFK1;PFKA;PPP1R122
Species	Human
Expression_host	Baculovirus-Insect Cells
Sequence	Thr 2-Val 780
Accession	P08237-1
Mol_Mass	112.9 kDa
AP_Mol_Mass	113 kDa
Tag	N-His-GST

Properties

Purity	> 90 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as sterile solution of 20mM Tris, 500mM NaCl, pH 8.5, 10% glycerol
Reconstitution	Not Applicable

Background

PFK1, also known as PFKM, is a regulatory glycolytic enzyme. PFK1 converts fructose 6-phosphate and ATP into fructose 1,6-bisphosphate (through PFK-1), fructose 2,6-bisphosphate (through PFK-2) and ADP. It is a muscle-type isozyme. There are three phosphofructokinase isozymes in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Mutations in PFK1 gene have been related with glycogen storage disease type VII, also identified as Tarui disease.

Citations

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