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Recombinant Human PGD2 Synthase/PTGDS Protein (His Tag)

Citations(1)Uniprot : P41222

Cat.No.:PKSH030653
Expression host: HEK293 Cells

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Description

Synonyms	Prostaglandin D Synthase;Prostaglandin-H2 D-Isomerase;Beta-Trace Protein;Cerebrin-28;Glutathione-Independent PGD Synthase;Lipocalin-Type Prostaglandin-D Synthase;Prostaglandin-D2 Synthase;PGD2 Synthase;PGDS;PGDS2;PTGDS;PDS
Species	Human
Expression_host	HEK293 Cells
Sequence	Ala23-Gln190
Accession	P41222
Mol_Mass	19.7 kDa
AP_Mol_Mass	20-27 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5.
Reconstitution	Not Applicable

Background

Prostaglandin-H2 D-Isomerase (PTGDS) belongs to the Lipocalin family of calycin superfamily. PTGDS is preferentially expressed in the brain. PTGDS catalyzes the conversion of PGH2 to PGD2; a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. PTGDS is involved in a variety of CNS functions; such as sedation; REM sleep and PGE2-induced allodynia; and may have an anti-apoptotic role in oligodendrocytes. PTGDS binds small non-substrate lipophilic molecules and may act as a scavenger for harmful hydrophopic molecules and a secretory retinoid and thyroid hormone transporter. It possibly participates in development and maintenance of the blood-brain; blood-retina; blood-aqueous humor; blood-testis barrier; the central nervous system and male reproductive system.

Citations

Metabolites (2022) IF: 4.932

High Correlation among Brain-Derived Major Protein Levels in Cerebrospinal Fluid: Implication for Amyloid-Beta and Tau Protein Changes in Alzheimer’s Disease

DOI: 10.3390/metabo12040355

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