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Recombinant Human PPIase/FKBP7 Protein (aa 1-218, His Tag)

Uniprot : Q9Y3C6
  • Cat.No.:PKSH030674

  • Expression host: HEK293 Cells

To Purchase PKSH030674

Size:
  • 100μg
Price: $855
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Description

Synonyms Peptidyl-Prolyl Cis-Trans Isomerase FKBP7;PPIase FKBP7;23 kDa FK506-Binding Protein;23 kDa FKBP;FKBP-23;FK506-Binding Protein 7;FKBP-7;Rotamase;FKBP7;FKBP23
Species Human
Expression_host HEK293 Cells
Sequence Met 1-Gln218
Accession Q9Y3C6
Mol_Mass 23.8 kDa
AP_Mol_Mass 27-30 kDa
Tag C-His

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.

Background

PPIase is a member of the immunophilin protein family. It also belongs to the cyclophilin-type PPIase family; PPIL3 subfamily. PPIase contains 1 PPIase cyclophilin-type domain. Members of the immunophilin protein family play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. It has a very high substrate specificity for the four-residue peptide Ala-Ala-Pro-Phe only when the proline peptide bond is in the trans state. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels; and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse; deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.

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