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Recombinant Human Proteinase 3/PRTN3 Protein (His Tag)

Uniprot : P24158

Cat.No.:PKSH032974
Expression host: HEK293 Cells

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Description

Synonyms	Myeloblastin;AGP7;C-ANCA Antigen;Leukocyte Proteinase 3;PR-3;PR3;Neutrophil Proteinase 4;NP-4;P29;Wegener Autoantigen;PRTN3;MBN
Species	Human
Expression_host	HEK293 Cells
Sequence	Ala26-Arg249
Accession	P24158
Mol_Mass	25.6 kDa
AP_Mol_Mass	34 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 10mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0.
Reconstitution	Not Applicable

Background

Proteinase-3 is a neutral serine proteinase that belongs to the peptidase S1 family and Elastase subfamily. It contains one peptidase S1 domain and it is expressed mainly in neutrophil granulocytes. The primary function of Proteinase-3 is thought to be degradation of extracellular proteins at sites of inflammation, but excessive or prolonged proteolytic activity may cause harmful effects in the body. It is the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.

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