Synonyms	SH2 Domain-Containing Protein 1A;Duncan Disease SH2-Protein;Signaling Lymphocytic Activation Molecule-Associated Protein;SLAM-Associated Protein;T-Cell Signal Transduction Molecule SAP;SH2D1A;DSHP;EBVS;IMD5;LYP;MTCP1;SAP/SH2D1A;XLP;XLPD;XLPD1
Species	Human
Expression_host	E.coli
Sequence	Pro 2-Lys 97
Accession	NP_002342.1
Application	Functional ELISA
Mol_Mass	15.6 kDa
AP_Mol_Mass	14 kDa
Tag	N-His
Bio_Activity	Measured by its ability to bind recombinant human SLAMF1, human SLAMF6, mouse SLAMF6, mouse CD84 in functional ELISA.

Properties

Purity	> 94 % as determined by reducing SDS-PAGE.
Endotoxin level	Please contact us for more information.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from sterile PBS, pH 7.5, 20% glycerol Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

SH2 domain-containing protein 1A (SH2D1A / SAP) is a 128 amino acid protein, containing a single Src homology 2 (SH2) domain, flanked by 5 amino acids at the N-terminus and 25 amino acids at the C-terminus. The absence of a catalytic domain and the presence of an SH2 domain suggest that SH2D1A regulates one or more signal transduction pathways. SH2D1A interacts with signaling lymphocytic activation molecule (SLAM), which is a transmembrane protein expressed on the surface of activated T and B cells. SH2D1A (SAP) interacts via its SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of the cell-surface receptors, including CD150 / SLAM, CD84, CD229 / Ly-9, and CD244 / 2B4. SH2D1A was expressed in EBV-carrying, tumor phenotype representative (type I), but not in EBV-carrying lymphoblastoid cell line (LCL)-like (type III) or EBV-negative Burkitt lymphoma (BL) lines. It has been supposed to be related to the X-linked lymphoproliferative disease which is also known as Duncan's disease or Purtilo syndrome.

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