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Recombinant Human SIAE Protein (Human Cells, His Tag)

Uniprot : Q9HAT2

Cat.No.:PKSH033053
Expression host: HEK293 Cells

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Description

Synonyms	Sialate O-Acetylesterase;H-Lse;Sialic Acid-Specific 9-O-Acetylesterase;SIAE;YSG2;AIS6;CSE-C;CSEC
Species	Human
Expression_host	HEK293 Cells
Sequence	Ile24-Lys523
Accession	Q9HAT2
Mol_Mass	57.0 kDa
AP_Mol_Mass	55-80 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5.
Reconstitution	Not Applicable

Background

Sialate O-Acetylesterase (SIAE) belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. SIAE is widely expressed with high expression levels in the testis, prostate, and colon. SIAE catalyzes N-acetyl-O-acetylneuraminate and H2O to N-acetylneuraminate and acetate. SIAE removes O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid. SIAE down-regulates B lymphocyte antigen receptor signaling (involving CD22), and is required for immunological tolerance. Loss of function mutations in SIAE are much more frequently found in humans with autoimmune diseases especially rheumatoid arthritis and type 1 diabetes.

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