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Recombinant Human Sialidase-1/NEU-1 Protein (His Tag)

Uniprot : Q99519

Cat.No.:PKSH033056
Expression host: HEK293 Cells

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Description

Synonyms	Sialidase-1;Acetylneuraminyl Hydrolase;G9 Sialidase;Lysosomal Sialidase;N-Acetyl-Alpha-Neuraminidase 1;NEU1;NANH
Species	Human
Expression_host	HEK293 Cells
Sequence	Glu48-Leu415
Accession	Q99519
Mol_Mass	41.3 kDa
AP_Mol_Mass	39-50 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 50% Glycerol, pH 7.4.
Reconstitution	Not Applicable

Background

Sialidase-1 belongs to the N-acetyl-a neuraminidase family. Sialidase-1 is expressed in many tissues; it is highly expressed in the pancreas, and weakly expressed in the brain. Sialidase-1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Deficiencies in the human enzyme Sialidase-1 leads to sialidosis, a rare lysosomal storage disease. Sialidase-1 has been shown to interact with Cathepsin A (protective protein), β-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.

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