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Recombinant Human STING/TMEM173 Protein (Sumo & His Tag)

Uniprot : Q86WV6

Cat.No.:PKSH033517
Expression host: E.coli

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Description

Synonyms	Stimulator of interferon genes protein;TMEM173;Mediator of IRF3 activation;sting;
Species	Human
Expression_host	E.coli
Sequence	Val155-Val341
Accession	Q86WV6
Mol_Mass	33.8 kDa
AP_Mol_Mass	35 kDa
Tag	N-SUMO-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM HEPES, 100mM NaCl, 10% Glycerol, pH8.0.
Reconstitution	Not Applicable

Background

Stimulator of Interferon Gene(Sting,TMEM173) belongs to the TMEM173 family. STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a C-terminal cytoplasmic domain (aa 174-379). It ubiquitously expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophagesand. Its subunit structure associated with the MHC-II complex and Interacts with DDX58/RIG-I, MAVS and SSR2, RNF5 and TRIM56 along with TBK1. This type of protein often uses as facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon.

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