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Recombinant Mouse ALK-1/ACVRL1 Protein (His & Fc Tag)

Uniprot : Q61288
  • Cat.No.:PKSM040803

  • Expression host: HEK293 Cells

To Purchase PKSM040803

Size:
  • 200μg
Price: $1210
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Description

Synonyms Serine/threonine-protein kinase receptor R3;SKR3;Activin receptor-like kinase 1;ALK-1;TGF-B superfamily receptor type I;TSR-I;ACVRL1;activin A receptor type II-like 1;activin A receptor
Species Mouse
Expression_host HEK293 Cells
Sequence Met 1-Pro 119
Accession NP_033742.2
Mol_Mass 39.0 kDa
AP_Mol_Mass 50-55 kDa
Tag C-His-Fc
Bio_Activity Measured by its ability to inhibit BMP9-induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953. The ED50 for this effect is typically 60-300 ng/mL in the presence of 2 ng/mL of recombiant human BMP9.

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.

Background

Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.

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