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Recombinant Mouse CD226/DNAM-1 Protein (His Tag)

  • Cat.No.:PKSM041233

  • Expression host: HEK293 Cells

To Purchase PKSM041233

Size:
  • 10μg
  • 50μg
Price: $117
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Description

Synonyms CD226 antigen;platelet and T cell activation antigen 1;CD226 molecule;DNAM1 adhesion glycoprotein;DNAM-1;DNAX accessory molecule-1;DNAX accessory molecule 1;PTA1;T lineage-specific activation antigen 1 antigen;CD226;PTA1;TLiSA1;BC051526;DNAM-1;DNAM1;Pta1;TLiSA1
Species Mouse
Expression_host HEK293 Cells
Sequence Glu19-Pro254
Accession Q8K4F0
Mol_Mass 27.6 kDa
AP_Mol_Mass 35-50 kDa
Tag C-His

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.

Background

Mouse DNAX accessory molecule-1(DNAM-1) is a type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily. As an activating receptor, it interacts with the ligands CD155 and CD112, and activates natural killer (NK) cells via its immu-noreceptor tyrosine-based activatory motif (ITAM). Mature mouse DNAM-1 has extracellular domain (ECD) that contains two Ig-like C2-set domains, and possesses a cytoplasmic region that contains motifs for binding PDZ domains. DNAM-1 is expressed on several lymphoid and myeloid cell types and interacts with CD155/PVR and Nectin-2/CD112. Ligation of DNAM-1 promotes the activation of NK cells, CD8+ T cells, and mast cells, induces dendritic cell maturation, initiates megakaryocyte and activated platelet adhesion to vascular endothelial cells, and stimulates monocyte extravasation? Conversely, it inhibits the formation of osteoclasts. Platelet-endothelium interactions that are mediated by DNAM-1 enable the metastasis of tumor cells to the lung.

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