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Recombinant Mouse Neurotrophic Tyrosine Kinase Receptor Type 2/TrkB/NTRK2 (C-6His)

Uniprot : P15209

Cat.No.:PKSM041430
Expression host: HEK293 Cells

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Description

Synonyms	BDNF/NT-3 Growth Factors Receptor;GP145-TrkB;Trk-B;Neurotrophic Tyrosine Kinase Receptor Type 2;TrkB Tyrosine Kinase;Tropomyosin-Related Kinase B;NTRK2;TRKB
Species	Mouse
Expression_host	HEK293 Cells
Sequence	Cys32-His429
Accession	P15209
Mol_Mass	45.3 kDa
AP_Mol_Mass	60-90 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

The TRK Family of Tyrosine Kinase Receptor consists of 3 members: TrkA, TrkB and TrkC. The three TRK family proteins have different ligand specificities. They connect to different neurotrophins, including NGF, BDNF, NT-3NT-4/5. TRKA binds NGF, TRKB binds BDNF and NT-3, TRKC binds NT-4/5. At the protein sequence level, human and rat TRKB have greater than 90% sequence identity and the proteins exbihit cross-species activity. TRKB is primarily expressed in the nervous system and it also expression in a wide variety of tissues with low levels.

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