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Recombinant Mouse Tie2/CD202b Protein (aa 770-1122, His & GST Tag)

Uniprot : Q02858
  • Cat.No.:PKSM040369

  • Expression host: Baculovirus-Insect Cells

To Purchase PKSM040369

Size:
  • 50μg
Price: $486
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Description

Synonyms AA517024;Cd202b;Hyk;STK1;Tie-2;Tie2
Species Mouse
Expression_host Baculovirus-Insect Cells
Sequence Gln770-Ala1122
Accession Q02858
Application Functional ELISA
Mol_Mass 68.2 kDa
AP_Mol_Mass 68 kDa
Tag N-His-GST
Bio_Activity 1. No Kinase Activity.
2. Immobilized mouse TEK (aa 770-1122) at 2 μg/ml (100 μl/well) can bind human Ang2-Fc with a linear range of 0.25-2.0 μg/ml.

Properties

Purity > 91 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 10% glycerol
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.

Background

TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.

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