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Recombinant Rat HER2/ErbB2 Protein (aa 67-323, His Tag)

Uniprot : P06494

Cat.No.:PKSR030455
Expression host: E.coli

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Description

Synonyms	Receptor tyrosine-protein kinase erbB-2;Epidermal growth factor receptor-related protein;Proto-oncogene Neu;Proto-oncogene c-ErbB-2;p185erbB2;p185neu;CD340;ERBB2;ENV;ENVW;ERVWE1;HER-2;HER-2/neu;HER2;HERV-7q;HERV-W-ENV;HERV7Q;HERVW;HERVWENV;MLN 19;MLN19
Species	Rat
Expression_host	E.coli
Sequence	Ala67-Val323
Accession	P06494
Mol_Mass	29.3 kDa
AP_Mol_Mass	32 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, 5% Trehalose, 4M Urea, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the prin
Reconstitution	Please refer to the printed manual for detailed information.

Background

ERBB2 belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. It contains a protein kinase domain. ERBB2 is widely expressed in epithelial cells, and amplification and/or overexpression of ErbB2 has been reported associated with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate and ovarian cancers. Rat ERBB2 is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. ErbB2 mediates signalling pathways which involve mitogen-activated protein kinase and phosphatidylinositol-3 kinase, this receptor plays a key role in development, cell proliferation and differentiation.

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