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Recombinant Human SerpinB3/SCCA1 Protein (E.coli, His Tag)

Uniprot : P29508

Cat.No.:PKSH033038
Expression host: E.coli

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Description

Synonyms	Serpin B3;Protein T4-A;Squamous cell carcinoma antigen 1;SCCA-1;serine (or cysteine) proteinase inhibitor;clade B (ovalbumin);member 3;serpin peptidase inhibitor;clade B (ovalbumin);member 3;Squamous cell carcinoma antigen 1;T4-A;SCCA1;HsT1196;SCC;SCCA-1;SCCA-PD
Species	Human
Expression_host	E.coli
Sequence	Met 1-Pro390
Accession	P29508
Mol_Mass	46.0 kDa
AP_Mol_Mass	40-55 kDa
Tag	N-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Serpin B3, also known as squamous cell carcinoma antigen-1 (SCCA-1), is a member of the serpin superfamily of serine protease inhibitors. Serpin B3 belongs to the subgroup ovalbumin-related serpins which are involved in the regulation of apoptosis, inflammation, angiogenesis and embryogenesis. It may act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. It also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).

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