BRCA2 Polyclonal Antibody

Uniprot : P51587
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-40288

      Synonyms:BRCA 2,BRCA1/BRCA2 containing complex subunit 2,Brca2,BRCA2,DNA repair associated,BRCA2,BRCC 2,BRCC2,Breast and ovarian cancer susceptibility gene early onset,breast and ovarian cancer susceptibility protein 2,Breast cancer 2 early onset,Breast Cancer 2 tumor suppressor,Breast cancer susceptibility protein BRCA2,Breast cancer type 2 susceptibility protein,BROVCA2,FACD,FAD 1,FAD,FAD1,FANCB,FANCD 1,FANCD,FANCD1,FANCD1 gene,Fanconi anemia complementation group D1,Fanconi anemia group D1 protein,GLM3,mutant BRCA2,OTTHUMP00000018803,OTTHUMP00000042401,PNCA2,XRCC11

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,R

      Applications: WB,IHC,IF

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms BRCA 2,BRCA1/BRCA2 containing complex subunit 2,Brca2,BRCA2,DNA repair associated,BRCA2,BRCC 2,BRCC2,Breast and ovarian cancer susceptibility gene early onset,breast and ovarian cancer susceptibility protein 2,Breast cancer 2 early onset,Breast Cancer 2 tumor suppressor,Breast cancer susceptibility protein BRCA2,Breast cancer type 2 susceptibility protein,BROVCA2,FACD,FAD 1,FAD,FAD1,FANCB,FANCD 1,FANCD,FANCD1,FANCD1 gene,Fanconi anemia complementation group D1,Fanconi anemia group D1 protein,GLM3,mutant BRCA2,OTTHUMP00000018803,OTTHUMP00000042401,PNCA2,XRCC11
      Swissprot P51587
      Source Rabbit
      Reactivity Human,Rat
      Immunogen Recombinant Human Breast cancer type 2 susceptibility protein
      Application WB,IHC,IF
      Recommended dilution WB 1:1000-1:3000 IHC 1:100-1:200 IF 1:100-1:400
      Concentration 1mg/mL

      Properties

      Cellular localization Nucleus. Cytoskeleton
      Isotype IgG
      Purification Antigen Affinity Purification
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
      Background Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

      Images

      Western Blot analysis of Jurkat, MCF-7 and A431 cells using BRCA2 Polyclonal Antibody at dilution of 1:2000

      Western Blot analysis of Hela cells using BRCA2 Polyclonal Antibody at dilution of 1:2000

      Western Blot analysis of Rat testis using BRCA2 Polyclonal Antibody at dilution of 1:2000

      Immunohistochemistry of paraffin-embedded Human colon using BRCA2 Polyclonal Antibody at dilution of 1:100

      Immunofluorescence analysis of U-2OS cells using BRCA2 Polyclonal Antibody at dilution of 1:100

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