p16 Polyclonal Antibody

Uniprot : Q9R0Z3
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-40264

      Synonyms:CCM2,CDK4 inhibitor p16 INK4,CDK4I,CDKN2,CDKN2A,Cell cycle negative regulator beta,CMM2,Cyclin dependent kinase 4 inhibitor A,Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4),Cyclin Dependent Kinase Inhibitor 2A,Cyclin dependent kinase inhibitor 2A isoform 4,Cyclin dependent kinase inhibitor 2A isoforms 1/2/3,Cyclin dependent kinase inhibitor p16,INK4,INK4A,MLM,MTS1,Multiple tumor suppressor 1,p14,p16,P16INK4,p16INK4a,p19,p19Arf,TP16

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $60

      Host: Rabbit

      Reactivity: H,R

      Applications: IHC

      Lead Time: 7~10daysWelcome to order from local distributors.

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      Overview

      Synonyms CCM2,CDK4 inhibitor p16 INK4,CDK4I,CDKN2,CDKN2A,Cell cycle negative regulator beta,CMM2,Cyclin dependent kinase 4 inhibitor A,Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4),Cyclin Dependent Kinase Inhibitor 2A,Cyclin dependent kinase inhibitor 2A isoform 4,Cyclin dependent kinase inhibitor 2A isoforms 1/2/3,Cyclin dependent kinase inhibitor p16,INK4,INK4A,MLM,MTS1,Multiple tumor suppressor 1,p14,p16,P16INK4,p16INK4a,p19,p19Arf,TP16
      Swissprot Q9R0Z3
      Source Rabbit
      Reactivity Human,Rat
      Immunogen Recombinant Rat Cyclin-dependent kinase inhibitor 2A protein
      Application IHC
      Recommended dilution IHC 1:50-1:200
      Concentration 0.82mg/mL

      Properties

      Cellular localization Cytoplasmic and Nuclear
      Tissue specificity Expressed in spleen, liver and lung. Not detected in kidney, colon, stomach or brain.
      Isotype IgG
      Purification Antigen Affinity Purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
      Background This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. 

      Images

      Immunohistochemistry of paraffin-embedded Rat liver using P16 Polyclonal Antibody at dilution of 1:100

      Immunohistochemistry of paraffin-embedded Human ovarian using P16 Polyclonal Antibody at dilution of 1:100

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